Open and Recruiting
Clinical Trials

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  A First-in-Human Phase 1a/1b Trial of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors

  • Sponsor

    Eli Lilly and Company

  • Trial ID

    NCT06586515

  • Study Details

    Study Details | MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors | ClinicalTrials.gov

  • Study Url

    https://clinicaltrials.gov/study/NCT06586515?term=LY3962673&rank=1

  • Cancer Type

    KRAS G12D-mutant advanced solid tumors

  • Status

    Recruiting

  Brief Summary

  The main purpose of this study is to assess safety & tolerability and antitumor activity of LY3962673 as monotherapy and in combination with other chemotherapy agents in participants with KRAS G12D-mutant advanced solid tumor types.

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  A Phase Ib Open Label Randomised Clinical Trial to Evaluate Safety and Efficacy of BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Compared With Pembrolizumab Monotherapy for the First-line Treatment of Patients With Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)

  • Sponsor

    Boehringer Ingelheim

  • Trial ID

    NCT06806852

  • Study Details

    Study Details | A Study to Test Whether Treatment With BI 770371 in Combination With Pembrolizumab With or Without Cetuximab Helps People With Head and Neck Cancer Compared With Pembrolizumab Alone | ClinicalTrials.gov

  • Study Url

    https://clinicaltrials.gov/study/NCT06806852?term=NCT06806852&rank=1

  • Cancer Type

    Metastatic or Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC)

  • Status

    Recruiting

  Brief Summary

  The tested medicines in this study are antibodies that act in different ways against cancer. BI 770371 and pembrolizumab may help the immune system fight cancer. This study is open to adults with head and neck cancer. The purpose of this study is to find out whether combining different study medicines makes tumors shrink in people with head and neck cancer.
  

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  Phase 1/2, First-in-Human, Open-label, Multicenter, Study of DS-3939a in Subjects With Advanced Solid Tumors

  • Sponsor

    Daiichi Sankyo

  • Trial ID

    NCT05875168

  • Study Details

    Study Details | First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors | ClinicalTrials.gov

  • Study Url

    https://clinicaltrials.gov/study/NCT05875168?term=NCT05875168&rank=1

  • Cancer Type

    Advanced or Metastatic Solid Tumors

  • Status

    Recruiting

  Brief Summary

  DS-3939a is an antibody drug conjugate (ADC) being developed for the treatment of malignant tumors. This is a first-in-human, dose-escalating clinical study divided into 2 parts: the Dose Escalation Part (Part 1) and the Dose Expansion Part (Part 2). This study will evaluate the safety, tolerability, and efficacy of DS-3939a in participants with advanced solid tumors.
  

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  A First-in-Human Phase 1, Open-Label, Multicenter Study of INCA33890 in Participants With Advanced or Metastatic Solid Tumors

  • Sponsor

    Incyte Corporation

  • Trial ID

    NCT05836324

  • Study Details

    Study Details | A Study to Evaluate the Safety of INCA33890 in Participants With Advanced or Metastatic Solid Tumors | ClinicalTrials.gov

  • Study Url

    https://clinicaltrials.gov/study/NCT05836324?intr=NCT05836324&rank=1

  • Cancer Type

    Advanced or Metastatic Solid Tumors

  • Status

    Recruiting

  Brief Summary

  To evaluate the safety, tolerability, and DLTs and determine the MTD and/or RDE(s) of INCA33890 in participants with select advanced or metastatic solid tumors.

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