関西科大学附属病院 新薬開発科

Department of New Experimental Therapeutics
Early-Phase 1 Drug Development Service
Kansai Medical University Hospital


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  • 論文実績
    • 2025年

      Lucassen MJJ, Bergmann P, Husson O, Banerji U, Basu B, Melero I, Calvo E, Cassier PA, Drilon A, Fong PC, Garralda E, Joshua AM, Lin CC, Lopez J, Moreno V, Minchom A, Plummer R, Postel-Vinay S, Spreafico A, Shimizu T, Yap TA, Yap C, De Bono JS, Steeghs N. Barriers to publishing early phase clinical trials: the oncologists’ perspective. Oncologist 2025 Apr 4;30(4):oyaf042.doi: 10.1093/oncolo/oyaf042.

      Hayato S, Hamuro L, Shimizu T, Yonemori K, Nishio S, Yunokawa M, Yoshida T, Nishio M, Matsumoto K, Takehara K, Hasegawa K, Kozuki T, Hirashima Y, Kato H, Miura T, Nomoto M, Zhao Y, Zhu L, Yasuda S. Pharmacokinetic and Exposure-Response Modeling Support Body Surface Area-Based Dosing of Farletuzumab Ecteribulin in Japanese Patients with Solid Tumors. J Clin Pharmacol. 2025 Jan 24. doi: 10.1002/jcph.6187. Online ahead of print.

      Hata, T., Yamada, T., Goto, Y., Amano, A., Negi, Y., Watanabe, S., Furuya, N., Oba, T., Ikoma, T., Nakao, A., Tanimura, K., Taniguchi, H., Yoshimura, A., Fukui, T., Murata, D., Kaira, K., Shiotsu, S., Hibino, M., Okada, A., Chihara, Y., … Takayama, K. (2025). Comparative analysis of first-line treatment in NSCLC including unresectable stage III (IIIB/IIIC) and stage IV with low PD-L1 expression: Clinical trial eligible versus ineligible patients. Lung cancer (Amsterdam, Netherlands), 200, 108104. https://doi.org/10.1016/j.lungcan.2025.108104

      Hata, T., Yamada, T., Goto, Y., Amano, A., Negi, Y., Watanabe, S., Furuya, N., Oba, T., Ikoma, T., Nakao, A., Tanimura, K., Taniguchi, H., Yoshimura, A., Fukui, T., Murata, D., Kaira, K., Shiotsu, S., Hibino, M., Okada, A., Chihara, Y., … Takayama, K. (2025). Regimen Selection for Chemoimmunotherapy in Nonsquamous Non-Small Cell Lung Cancer with Low PD-L1 Expression: A Multicenter Retrospective Cohort Study. Clinical lung cancer, S1525-7304(25)00001-4. Advance online publication. https://doi.org/10.1016/j.cllc.2025.01.002

      Katsushima, U., Kurose, S., Fukushima, T., Nakano, J., Ogushi, N., Fujii, K., Nagata, Y., Kamisako, K., Okuno, Y., Okazaki, Y., Nakanishi, K., Yoshida, K., Ikoma, T., Takeyasu, Y., Yamanaka, Y., Yoshioka, H., Hase, K., & Kurata, T. (2025). Impact of time to treatment initiation on the development of cachexia and clinical outcomes in lung cancer. Japanese journal of clinical oncology, 55(5), 505–513. https://doi.org/10.1093/jjco/hyaf009

      Katsushima, U., Fukushima, T., Nakano, J., Ogushi, N., Fujii, K., Nagata, Y., Kamisako, K., Okuno, Y., Okazaki, Y., Nakanishi, K., Yoshida, K., Ikoma, T., Takeyasu, Y., Yamanaka, Y., Yoshioka, H., Hase, K., & Kurata, T. (2025). Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia. Thoracic cancer, 16(2), e15503. https://doi.org/10.1111/1759-7714.15503

      Nishioka, N., Hata, T., Yamada, T., Goto, Y., Amano, A., Negi, Y., Watanabe, S., Furuya, N., Oba, T., Ikoma, T., Nakao, A., Tanimura, K., Taniguchi, H., Yoshimura, A., Fukui, T., Murata, D., Kaira, K., Shiotsu, S., Hibino, M., Okada, A., … Takayama, K. (2025). Impact of TTF-1 Expression on the Prognostic Prediction of Patients with Non-Small Cell Lung Cancer with PD-L1 Expression Levels of 1% to 49%, Treated with Chemotherapy vs. Chemoimmunotherapy: A Multicenter, Retrospective Study. Cancer research and treatment, 57(2), 412–421. https://doi.org/10.4143/crt.2024.748

      Yamanaka, Y., Okuno, Y., Kamisako, K., Okazaki, Y., Nakanishi, K., Sanada, Y., Yoshida, K., Ikoma, T., Takeyasu, Y., Katsushima, U., Yoshioka, H., & Kurata, T. (2024). Efficacy and Safety Evaluation of Immune Checkpoint Inhibitors in Combination With Chemotherapy for Extensive Small Cell Lung Cancer: Real-World Evidence. Cancer medicine, 13(24), e70480. https://doi.org/10.1002/cam4.70480

      Ikoma, T., Matsumoto, T., Boku, S., Motoki, Y., Kinoshita, H., Kosaka, H., Kaibori, M., Inoue, K., Sekimoto, M., Fujisawa, T., Iwai, H., Naganuma, M., Tanizaki, H., Hisamatsu, Y., Okada, H., & Kurata, T. (2024). Safety of immune checkpoint inhibitors in patients aged over 80 years: a retrospective cohort study. Cancer immunology, immunotherapy : CII, 73(7), 126. https://doi.org/10.1007/s00262-024-03707-4

      Katsushima, U., Hase, K., Fukushima, T., Kubo, T., Nakano, J., Ogushi, N., Okuno, Y., Kamisako, K., Nakanishi, K., Okazaki, Y., Ikoma, T., Takeyasu, Y., Yamanaka, Y., Yoshioka, H., Imai, Y., & Kurata, T. (2024). Investigation of a practical assessment index to capture the clinical presentation of cachexia in patients with lung cancer. Japanese journal of clinical oncology, 54(3), 305–311. https://doi.org/10.1093/jjco/hyad177

  • 国内外の学会発表
  • 研究助成金獲得

Towards “Five-Stars” Phase 1 Center of Excellence

Department of New Experimental Therapeutics
Early-Phase 1 Drug Development Service